ANTIGENIC AND PROTECTIVE PROPERTIES OF ASSOCIATED VIRUS VACCINE AGAINST SHEEP POX, GOAT POX AND PESTE DES PETITS RUMINANTS

H^t of occurrence of sheep and goat pox and peste des petits rum^nts requires development of new vaccines and improvement of available associated ones. Their administration allows for the reduction of vaccination time frames and cost. The study results demonstrated tat associated as well as monovalent virus vaccines against sheep pox, goat pox and peste des petits rum^nts have good antigenic properties. The vaccination induced high level of virus neutralizing antibodies against each of the above listed diseases and ensured formation of strong immunity tat is supported by the results of tallenge of sheep with virulent sheep pox virus (“Afghanistan” strain). In 14 and 21 days in blood of sheep immunized with the virus vaccine against sheep pox, goat pox and peste des petits rum^nts titres of antibodies against sheep pox virus ((4.17±0.12)-(4.84±0.31)) and PPR ((5.92±0.23)-(6.08±0.23)) were higher as compared to goat pox antibody titres ((1.99±0.89)-(3.53±0.58) log₂). Herewith, antibody titres in blood sera of animals vaccinated with monovalent vaccine against sheep pox were higher against homologous virus ((3.62±0.12)- (4.08±0.31)) as compared to goat pox ((2.50±0.50)-(2.25±0.25) log₂). The data demonstrate tat the associated vaccines may be used for preventive vaccination against sheep pox, goat pox and peste des petits rum^nts.

оспа овец, оспа коз, чума мелких жвачных, овцы, козы, вируснейтрализующие антитела, вирусвакцина, сыворотка крови, иммунитет, sheep pox, goat pox, peste des petits rum^nts, sheep, goats, virus neutralizing antibodies, virus vaccine, blood serum, immunity

1. Басова Д.К., Диев В.И. Уровень антител в крови вакцинированных против оспы овец и их устойчивость при контрольном заражении // Достижения молодых ученых - в ветеринарную практику. - Владимир, 2000. - C. 57-61.

2. Изучение антигенных и иммуногенных свойств экспериментальной ассоциированной вакцины против оспы овец, оспы коз и чумы мелких жвачных / Н.В. Мороз, В.И. Диев, Е.В. Капускин, М.С. Кукушкина // Тр. Федерального центра охраны здоровья животных: материалы Междунар. конф., посвящ. 50-летию ФГБУ «ВНИИЗЖ». - Владимир, 2008. - Т. 6. - С. 266-272.

3. Мониторинг мировой эпизоотической ситуации по чуме мелких жвачных животных и прогноз ее распространения в 2015-2018 гг. / А.В. Книзе, С.В. Парилов, М.В. Болгова [и др.] // Актуальные вопросы ветеринарной биологии. - 2014. - № 4 (24). - С. 15-20.

4. Разработка ассоциированной вакцины против оспы овец и чумы мелких жвачных животных / В.М. Балышев, С.В. Парилов, Ю.Ф. Калантаенко [и др.] // Ветеринария. - 2010. - № 9. - С. 21-24.

5. A bivalent vaccine against goat pox and peste des petits ruminants induced protective immune response in goats / M. Hosamani, S.K. Singh, B. Mondal [et al.] // Vaccine. - 2006. - Vol. 24. - P. 6058-6064.

6. A Vero cell derived combined vaccine against sheep pox and peste des petits ruminants for sheep / S. S. Chaudhary, K.D. Pandey, R. P. Singh [et al.] // Vaccine. - 2009. -Vol. 27. - P. 2548-2553.

7. Estimation of post-vaccination antibody titre against goat pox and determination of protective antibody titre / D. Barman, A. Chatterijee, C. Guha [et al.] // Small Ruminant Research. - 2010. - Vol. 93. - P. 76-78.

8. Global strategy for the control and eradication of PPR / FAO/OIE. - Rome: FAO; Paris: OIE, 2015. - 83 p.

9. Manual of Diagnostic Tests and Vaccines for Terrestial Animals (mammals, birds and bees) / OIE. - Paris, 2017. -URL: http://www.oie.int/international-standard-setting/terrestrial-manual/access-online/.

10. World Animal Health Information Database (WAHYD) Interface / OIE. - URL: http://www.oie.int./wahis2public/wahid.php/wahidhome/Home.