HEPATOPROTECTIVE EFFECT OF LECITHIN-BASED PREPARATION ON EXPERIMENTAL ANIMAL LIVER TOXICITY

Data on assessment of lecithin preparation effect on liver toxicity experimentally induced in laboratory animals are presented. Experiments were carried out in rats kept under similar conditions that had been subjected to quarantine in animal facilities and demonstrated no apparent disease manifestations. The animals were divided into groups based on paired counterparts’ principle. Acute toxic damage of liver was induced by single administration of carbon tetrachloride (0.3 mg/kg of body weight). The rats demonstrated the following apparent signs of intoxication on day 2 after administration: anorexia, depression, dyspnea, fever.Per os administration of rape lecithin at a dose of 1 ml/kg of body weight one hour before hepatotoxicant administration and then daily for subsequent 30 days reduces intoxication manifestations and improves survivability of the rats. Pharmacological effect of lecithin includes biochemical characteristics improvement and functional state of liver of laboratory animals with experimentally induced acute hepatitis. Obtained data may provide grounds for application of lecithins as hepatoprotectors of natural origin in the form of biologically active supplements or active ingredients of pharmaceuticals intended for hepatic disease treatment in animals.

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