Study of pathogenesis and immune response at experimental infection of broiler chicks with avian metapneumovirus subtype В
Abstract
Experimental infection of 7-day-old chicks with the isolate of avian metapneumovirus Subtype В induced mild signs of respiratory infection and swelled infraorbital sinuses in 5-15 days post infection. Lesions in tissues of trachea, nasal passages and primary lymphoid organs were reported. Using real-time RT-PCR avian metapneumovirus genome was detected in the upper part of the respiratory tract, infraorbital sinuses and Harderian gland within 2-12 days post infection. The immune response was characterized by formation of humoral and local antibodies in 7-21 days post infection. In 3 days post infection increased percentage of CD8a+ T-cell subpopulation was reported in blood and spleen of the infected chicks.
About the Authors
M. A. Volkova
FGBI "ARRIAH", Vladimir
Russian Federation
Russian Federation
P. S. Yaroslavtseva
FGBI "ARRIAH", Vladimir
Russian Federation
Russian Federation
V. Yu. Sosi Pato Rova
FGBI "ARRIAH", Vladimir
Russian Federation
Russian Federation
T. L. Eroshina
FGBI "ARRIAH", Vladimir
Russian Federation
Russian Federation
I. A. Chvala
FGBI "ARRIAH", Vladimir
Russian Federation
Russian Federation
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Review
For citations:
Volkova M.A., Yaroslavtseva P.S., Sosi Pato Rova V.Yu., Eroshina T.L., Chvala I.A. Study of pathogenesis and immune response at experimental infection of broiler chicks with avian metapneumovirus subtype В. Veterinary Science Today. 2016;(4):29-34. (In Russ.)
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