Effect of bacterial lysate immunomodulator on key hematological parameters and functional activity of piglets’ immune system during post-weaning

Introduction. Post-weaning period in pig production is a critical phase that determines the herd’s future productivity and health. Stress from dietary changes, regrouping, and altered microclimate leads to post-weaning syndrome. Its underlying mechanism is transient immunosuppression resulting from hyperactivity of the hypothalamic-pituitary-adrenal axis and increased cortisol levels. For this reason, it is essential to develop immunocorrective strategies during this period.

Objective. To assess impact of an oral polyvalent bacterial lysate immunomodulator (Bordetella bronchiseptica, Haemophilus parasuis, and Streptococcus suis) on hematological parameters and immune system activation of piglets.

Materials and methods. Sixty blood samples of piglets taken from April to July 2024 on a pig farm in the Moscow Oblast were tested. Laboratory tests were conducted at the Russian State Agrarian University – Moscow Timiryazev Agricultural Academy using a hematology analyzer. Statistical analysis was performed using Statistica v.13.0.

Results. In a three-phase experiment involving experimental and control groups of piglets (n = 30), a course-based approach to Immbaclys C use induced pronounced changes in hematological parameters. A statistically significant and reproducible trend toward activation of the immunity lymphocyte component was revealed. All parameters remained within the normal range, indicating no negative impact of the tested medication on the hematopoiesis.

Conclusion. Three courses of Immbaclys C (14 days per one course, with a 21-day interval) induced a sustained immunostimulatory effect in piglets, along with im proved zootechnical parameters. Hematological analysis revealed no deviations from normal values, confirming good tolerability and safety profile of the medication

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