The use of Kutikulin for treatment and prevention of gastrointestinal diseases in calves and piglets

The global economy dictates more and more stringent  requirements  for the quality and volumes of products consumed. Veterinary professionals have to look for medicinal products that have a sparing effect on the animal body and, at the same time, are capable of eliminating  disease causes. The paper presents  the results of tests of Kutikulin, a product made at the Vologda Branch of the FSC VIEV, which consists of chicken gizzard cuticle containing a keratoid secretion and a number of biologically active enzymes. It is a non-toxic, water-insoluble, odourless yellow-green powder with a bitterish taste. When Kutikulin was used to treat newborn calves with a mild dyspepsia resulting from various alimentary causes, the disease duration averaged 2.9 days, recovery rates in the groups were approximately the same (96.6–96.9%). Kutikulin treatment of older calves allowed to reduce the duration of treatment by almost a day, to increase recovery rates by 4.8% and to decrease the number of deaths by 1.6 times.When used for preventive purposes in weaned piglets, Kutikulin helped to decrease morbidity in groups 1, 3 and 5 (test groups) by 2.7, 8.9 and 1.8 times, respectively, as compared with control groups. Its preventive effectiveness was found to be the highest in group 3 (test) piglets that received Kutikulin on a group basis with a liquid feed at a dose of 1.0 g once a day during 3 consecutive days. Along with a shorter disease duration, test group animals also demonstrated  less pronounced clinical symptoms. Thus, the use of Kutikulin reduces gastrointestinal disease morbidity and mortality in calves and piglets.

1. Mavlyutova A. G., Sidorova K. A. Otsenka sostoyaniya organizma porosyat pri ispol’zovanii biostimulyatorov = Body condition assessment in biostimulant-treated piglets. Aktual’nye voprosy nauki i hozjajstva: novye vyzovyireshenija: materialyLI Mezhdunarodnoj studencheskoj nauchno-prakticheskoj konferencii = Topical issues of science and economy: new challenges and solutions: proceedings of the LI International Student Research-to-Practice Conference (16 March 2017). Tyumen: Northern Trans-Ural SAU; 2017; 196–198. eLIBRARY ID: 30096732. (in Russ.)

2. Shikunova I. A. Sovremennyj mehanizm immunomoduljacii = Contemporary immunomodulation mechanism. VetPharma. 2012; 1–2 (6–7): 30–33. eLIBRARY ID: 20504287. (in Russ.)

3. Yakhin O. I., Lubyanov А. А., Yakhin I. А. Regarding the challenge of biostimulants legal and regulatory framework. Agricultural Chemistry. 2020; 9: 87–96. DOI: 10.31857/S0002188120090124. (in Russ.)

4. Makarova V. N., Simanova I. N., Badeeva O. B., Korukina M. V. Epizootological aspects of acute gastrointestinal diseases of newborn calves in the farms of the Vologda region. Veterinaria i kormlenie. 2019; 2: 26–27. DOI: 10.30917/ATT-VK-1814-9588-2019-2-9. (in Russ.)

5. Kotcumbas I. Y., Zhyla M. I., Shkodiak N. V., Pyatnychko O. M. The control methods of biological activity of modern veterinary immunomodulators. Scientific Messenger of Lviv National University of Veterinary Medicine and Biotechnologies. 2014; 16 (2-2): 165–174. eLIBRARY ID: 25480853. (in Ukrainian)

6. Fedota N. V. Gematologicheskie pokazateli i matematicheskoe modelirovanie bioritmov prirosta zhivoj massy u ovec pri dejstvii biostimuljatorov= Hematological parameters and mathematical modeling of live weight gain biorhythms in biostimulant-treated sheep: author’s abstract of Candidate of Science (Biology) thesis. Stavropol; 1998. 24 p. eLIBRARY ID: 30233652. (in Russ.)

7. Ostrickova E. Е. Dynamics morphological composition of the blood repair pigs at used probiotics and biostimulators. Veterinarnaya patologiya. 2012; 2: 67–69. eLIBRARY ID: 17878417. (in Russ.)

8. Volynkina M. G., Ivanova I. E. Ispol’zovanie biostimuljatora pri vyrashhivanii porosjat = Biostimulant use in piglet rearing. The Electronic Scientific Journal. 2017; 1-1 (16): 16–18. eLIBRARY ID: 28773239. (in Russ.)

9. Krasnova O. A., Lazareva K. V. Growth and development of black-pied bull calves when using a biostimulator. Proceedings of Gorsky State Agrarian University. 2021; 58 (3): 83–87. eLIBRARY ID: 46596796. (in Russ.)

10. Daricheva N. N., Ermolaev V. A. Tissue therapy in veterinary medicine. Ulyanovsk: Ulyanovsk SAA; 2011. 168 p. eLIBRARY ID: 19517178. (in Russ.)

11. Pushkarev I. A., Kureninova T. V., Shanshin N. V., Belyaeva N. Yu. The effect of different doses of tissue bio-stimulant on blood serum protein composition in lactating cows. Bulletin of KrasSAU. 2020; 12: 96–101. DOI: 10.36718/1819-4036-2020-12-96-101. (in Russ.)

12. Kureninova T. V., Pushkarev I. A., Silivirova T. L., Shanshin N. V., Mironova A. V., Pushkarev V. A. The influence of a new tissue biostimulant on cow milk production level. Vestnik Altaiskogo SAU. 2019; 7 (177): 102–109. eLIBRARY ID: 41188987. (in Russ.)

13. Kudasheva A. V., Rogachev B. G., Seitov M. S., Provotorov N. K. Methods of treatment and prophylaxis of gastric-intestinal diseases in calves. Izvestia Orenburg State Agrarian University. 2009; 4 (24): 162–163. eLIBRARY ID: 12990643. (in Russ.)

14. Malkova N. N., Ostyakova M. E., Golaydo N. S., Irkhina V. K., Shcherbinina S. A., Gavrilov Yu. A., Gavrilova G. A. Alimentary-functional diarrhea of calves and its therapy. Agrarian Bulletin of the Urals. 2019; 181 (2): 29–35. DOI: 10.32417/article_5cb0aea9e2a880.36987343. (in Russ.)

15. Dmitriev A. F., Agarkov A. V. Development of a correction method for the immunobiological status of newborn animals. Proceedings of Gorsky State Agrarian University. 2017; 54 (3): 102–108. eLIBRARY ID: 30031121. (in Russ.)

16. Frolova M., Slozhenkina M., Mosolov A. Micro seaweeds – a natural biogrowth factor. Animal Husbandry of Russia. 2021; 9: 55–56. DOI: 10.25701/ZZR.2021.31.46.010. (in Russ.)

17. Makarova V. N., Koryukina M. V., Badeeva O. B., Simanova I. N. The use of immunostimulants for the animal diseases prevention. AGRITECH-IV-2020. IOP Conf. Ser.: Earth Environ. Sci. 2021; 677:052103. DOI: 10.1088/1755-1315/677/5/052103.

18. Ovsyannikov A. P., Sunagatullin F. A., Khayrullin D. D. The impact of a biological pacemaker according to V. P. Filatov, with the addition of microelements on biochemical composition of blood of calves. Scientific Notes Kazan Bauman State Academy of Veterinary. 2017; 231 (3): 112–114. eLIBRARY ID: 30016066. (in Russ.)

19. Bezborodov N., Bondarenko E. Primenenie immunomoduljatora timogena dlja lechenija teljat s funkcional’noj dispepsiej = The use of the immunomodulator Thymogen for treatment of calves with functional dyspepsia. Dairy and Beef Cattle Farming. 2009; 2: 24–26. eLIBRARY ID: 12913577. (in Russ.)

20. Petrova O. G., Alekseev A. D. The use of plant-tissue preparation for the treatment and prevention of gastrointestinal infections in calves in the Ural Region. Scientific-methodological electronic journal “Concept”. 2014; 20: 1046–1050. Available at: http://e-koncept.ru/2014/54473.htm. (in Russ.)

21. Kalashnik I. A. Tissue therapy in veterinary medicine. Moscow: Sel’khozgiz; 1960. 103 р. (in Russ.)

22. Fedota N. V., Sannikov M. Ju. Biorhythms of the growth in young rams under feeding preparation obtained from brain tissues. Problems of Productive Animal Biology. 2012; 1: 26–31. eLIBRARY ID: 17588050. (in Russ.)

23. Danilova L. G., Nekrasova I. I. Vlijanie dlitel’noj adaptacii k uslovijam juga Rossii na jekster’ernye i fiziologicheskie pokazateli pastush’ih sobak porody avstralijskij kelpi = The effect of a long term adaptation to southern Russia conditions on the exterior and physiological characteristics of Australian Kelpie sheepdogs. Scientific Notes Kazan Bauman State Academy of Veterinary. 2009; 196: 107–113. eLIBRARY ID: 22290710. (in Russ.)

24. Fedota N. V. Technology of activity increasing and prolongation of storage term of tissue preparations. The Agrarian Scientific Journal. 2012; 6: 42–43. eLIBRARY ID: 17786470. (in Russ.)

25. Linnik A. A., Alekseevа S. A., Kuznetsov О. Y. Efficiency of application of the new biostimulator in poultry farming. Bulletin of the Kursk State Agricultural Academy. 2015; 7: 151–153. eLIBRARY ID: 28899344. (in Russ.)

26. Ryzhkova G. F., Aleksandrova E. V., Evglevskij A. A., Evglevskaja E. P. Vlijanie biostimuljatorov na osnove jantarnoj kisloty na morfologicheskie i biohimicheskie pokazateli krovi cypljat-brojlerov = The effect of succinic acid-based biostimulants on the morphological and biochemical blood profile of broiler chickens. Bulletin of the Kursk State Agricultural Academy. 2011; 5: 71–73. eLIBRARY ID: 17704182. (in Russ.)