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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">veterinary</journal-id><journal-title-group><journal-title xml:lang="ru">Ветеринария сегодня</journal-title><trans-title-group xml:lang="en"><trans-title>Veterinary Science Today</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2304-196X</issn><issn pub-type="epub">2658-6959</issn><publisher><publisher-name>"Veinard"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29326/2304-196X-2025-14-1-32-39</article-id><article-id custom-type="elpub" pub-id-type="custom">veterinary-890</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ | БОЛЕЗНИ СВИНЕЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS | PORCINE DISEASES</subject></subj-group></article-categories><title-group><article-title>Профилактика респираторных болезней свиней вирусно-бактериальной этиологии в условиях импортозамещения</article-title><trans-title-group xml:lang="en"><trans-title>Prevention of respiratory diseases of pigs of viral-bacterial etiology in conditions of import substitution</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6411-6027</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Михалева</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mikhaleva</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Михалева Татьяна Владимировна, канд. вет. наук, ученый секретарь</p><p>ул. Магнитогорская, 8, г. Самара, 443013</p></bio><bio xml:lang="en"><p>Tatyana V. Mikhaleva, Cand. Sci. (Veterinary Medicine), Academic Secretary</p><p>8, Magnitogorskaya str., Samara 443013</p></bio><email xlink:type="simple">tatyanamihaleva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1282-7980</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коннова</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Konnova</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коннова Светлана Сергеевна, заместитель директора</p><p>ул. 53-й Стрелковой дивизии, 6, г. Саратов, 410028</p></bio><bio xml:lang="en"><p>Svetlana S. Konnova, Deputy Director, Saratov Research</p><p>6, 53 Strelkovoy divizii str., Saratov 410028</p></bio><email xlink:type="simple">konnovass@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Федеральный исследовательский центр вирусологии и микробиологии» (ФГБНУ ФИЦВиМ); Самарский научно-исследовательский ветеринарный институт – филиал ФГБНУ ФИЦВиМ (СамНИВИ – филиал ФГБНУ ФИЦВиМ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center for Virology and Microbiology; Samara Research Veterinary Institute – Branch of Federal Research Center for Virology and Microbiology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Федеральный исследовательский центр вирусологии и микробиологии» (ФГБНУ ФИЦВиМ); Саратовский научно-исследовательский ветеринарный институт – филиал ФГБНУ ФИЦВиМ (СарНИВИ – филиал ФГБНУ ФИЦВиМ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center for Virology and Microbiology; Saratov Research Veterinary Institute – Branch of Federal Research Center for Virology and Microbiology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>21</day><month>03</month><year>2025</year></pub-date><volume>14</volume><issue>1</issue><fpage>32</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Михалева Т.В., Коннова С.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Михалева Т.В., Коннова С.С.</copyright-holder><copyright-holder xml:lang="en">Mikhaleva T.V., Konnova S.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://veterinary.arriah.ru/jour/article/view/890">https://veterinary.arriah.ru/jour/article/view/890</self-uri><abstract><sec><title>Введение</title><p>Введение. Свиноводство, как скороспелая отрасль животноводства, способно в короткие сроки добиться существенного увеличения производства свинины с высокими пищевыми свойствами и биологической полноценностью. Одной из острых проблем отрасли являются респираторные болезни вирусно-бактериальной этиологии. В сложившихся экономических условиях особое значение приобретает снижение технологической импортозависимости российского свиноводства, поэтому выпуск кормовых и ветеринарных препаратов отечественного производства необходимо рассматривать как важнейшее условие достижения технологического суверенитета Российской Федерации.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Анализ обеспеченности свиноводства отечественными вакцинами против таких значимых респираторных болезней свиней, как грипп, энзоотическая (микоплазменная) пневмония, репродуктивно-респираторный синдром, цирковирусная инфекция, а также выявление факторов, которые препятствуют разработке иммунобиологических лекарственных препаратов против указанных заболеваний.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Информационной базой исследований являлись данные свиноводческих организаций Российской Федерации, государственный реестр лекарственных средств для ветеринарного применения Россельхознадзора, нормативно-справочная и специальная литература, публикации научно-исследовательских учреждений.</p></sec><sec><title>Результаты</title><p>Результаты. Возбудители гриппа, энзоотической (микоплазменной) пневмонии, репродуктивно-респираторного синдрома, цирковирусной инфекции являются наиболее распространенными патогенами, которые вызывают респираторные болезни свиней на свиноводческих комплексах. На протяжении последних лет российские биофабрики разрабатывают программы импортозамещения необходимых иммунобиологических лекарственных препаратов. По итогам 2023 г. отечественные предприятия выпустили 19,3 млрд доз вакцин для ветеринарного применения, что на 3 млрд доз больше по сравнению с 2022 г.</p></sec><sec><title>Заключение</title><p>Заключение. Вакцинация является наиболее эффективным и экономичным способом профилактики вирусных инфекций. Однако отечественные иммунологические лекарственные препараты против гриппа свиней еще не разработаны в нашей стране, а вакцины против энзоотической (микоплазменной) пневмонии, репродуктивно-респираторного синдрома, цирковирусной инфекции свиней требуют доработки в связи с высокой изменчивостью возбудителей.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Pig farming, as a fast-growing branch of animal husbandry, is capable of prompt achieving a significant increase in the production of pork with high nutritional properties and biological value. One of the acute problems of pig farming is respiratory diseases of viral and bacterial etiology. In the current economic conditions, reducing the dependence of the Russian pig farmingon technological imports is of particular significance. Production of domestically manufactured feeds and veterinary drugs should be considered as the most important condition for achieving the technological sovereignty of the Russian Federation.</p></sec><sec><title>Objective</title><p>Objective. To analyze the provision of pig farming with domestic vaccines against such significant porcine respiratory diseases as swine influenza, porcine enzootic (mycoplasmal pneumonia), porcine reproductive and respiratory syndrome and circovirus infection as well as to identify factors that hinder the development of immunobiological drugs against these diseases.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The information base of the research included data from pig-breeding organizations of the Russian Federation, the Rosselkhoznadzor’s state register of veterinary medicinal products, reference andspecial literature, publications of research institutions.</p></sec><sec><title>Results</title><p>Results. Agents of swine influenza, porcine enzootic (mycoplasmal) pneumonia, porcine reproductive and respiratory syndrome, porcine circovirus infection are the most prevalent pathogens that cause respiratory diseases in pig son the pig farms. Over the past few years, Russian biofactories havebeen developing import substitution programs for the necessary immunobiological drugs. By the end of 2023, the domestic establishments manufactured 19.3 billion doses of veterinary vaccines, which is 3 billion doses more than in 2022.</p></sec><sec><title>Conclusion</title><p>Conclusion. Vaccination is the most efficient and cost-effective way to prevent viral infections. However, domestic immunological drugs against swine influenza have not yet been developed in our country, and vaccines against porcine enzootic (mycoplasmal) pneumonia, porcine reproductive and respiratory syndrome, porcine circovirus infection require modification due to high variability of the agents.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>обзор</kwd><kwd>вакцины</kwd><kwd>импортозамещение</kwd><kwd>свиноводство</kwd><kwd>респираторные болезни свиней</kwd><kwd>национальная безопасность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>review</kwd><kwd>vaccines</kwd><kwd>import substitution</kwd><kwd>pig farming</kwd><kwd>porcine respiratory diseases</kwd><kwd>national security</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена при поддержке Минобрнауки России в рамках государственного задания ФГБНУ «Федеральный исследовательский центр вирусологии и микробиологии».</funding-statement><funding-statement xml:lang="en">The study was supported by the Ministry of Education and Science of the Russian Federation in the frame work of the State Assignment of the Federal Research Center for Virology and Microbiology.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">VanderWaal K., Deen J. 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