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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">veterinary</journal-id><journal-title-group><journal-title xml:lang="ru">Ветеринария сегодня</journal-title><trans-title-group xml:lang="en"><trans-title>Veterinary Science Today</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2304-196X</issn><issn pub-type="epub">2658-6959</issn><publisher><publisher-name>"Veinard"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29326/2304-196X-2023-12-4-354-362</article-id><article-id custom-type="elpub" pub-id-type="custom">veterinary-772</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ | БИОТЕХНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES | BIOTECHNOLOGY</subject></subj-group></article-categories><title-group><article-title>Влияние мезенхимных стволовых клеток на сперму животных при хранении</article-title><trans-title-group xml:lang="en"><trans-title>Effect of mesenchymal stem cells on animal semen during storage</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6750-640X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Закирова</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakirova</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Закирова Елена Юрьевна, кандидат биологических наук, ведущий научный сотрудник, заведующий научно-исследовательской лабораторией «Регенеративная ветеринария»</p><p>420008, Республика Татарстан, г. Казань, ул. Кремлевская, 18</p></bio><bio xml:lang="en"><p>Elena Yu. Zakirova, Candidate of Science (Biology), Leading Researcher, Head of  Research Laboratory for Veterinary Regenerative Medicine</p><p>420008, Republic of Tatarstan, Kazan, ul. Kremlevskaya, 18</p></bio><email xlink:type="simple">lenahamzina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4408-5363</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маланьева</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Malanyeva</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маланьева Альбина Геннадьевна, кандидат биологических наук, старший научный сотрудник научно-исследовательской лаборатории «Регенеративная ветеринария»</p><p>г. Казань, Республика Татарстан</p></bio><bio xml:lang="en"><p>Albina G. Malanyeva, Candidate of Science (Biology), Senior Researcher, Research Laboratory for Veterinary Regenerative Medicine</p><p>Kazan, Republic of Tatarstan</p></bio><email xlink:type="simple">aleksalbina@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1403-8635</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аймалетдинов</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Aimaletdinov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аймалетдинов Александр Маазович, кандидат биологических наук, старший научный сотрудник научно-исследовательской лаборатории «Регенеративная ветеринария»</p><p>г. Казань, Республика Татарстан</p></bio><bio xml:lang="en"><p>Аleksandr М. Aimaletdinov, Candidate of Science (Biology), Senior Researcher, Research Laboratory for Veterinary Regenerative Medicine</p><p>Kazan, Republic of Tatarstan</p></bio><email xlink:type="simple">allekss1982@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт фундаментальной медицины и биологии ФГАОУ ВО «Казанский (Приволжский) федеральный университет» (ИФМиБ КФУ)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute of Fundamental Medicine and Biology Kazan (Volga region) Federal University (IFMB KFU)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>20</day><month>12</month><year>2023</year></pub-date><volume>12</volume><issue>4</issue><fpage>354</fpage><lpage>362</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Закирова Е.Ю., Маланьева А.Г., Аймалетдинов А.М., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Закирова Е.Ю., Маланьева А.Г., Аймалетдинов А.М.</copyright-holder><copyright-holder xml:lang="en">Zakirova E.Y., Malanyeva A.G., Aimaletdinov A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://veterinary.arriah.ru/jour/article/view/772">https://veterinary.arriah.ru/jour/article/view/772</self-uri><abstract><p>Мезенхимные стволовые клетки известны человечеству с середины ХХв. Входе проведенного всестороннего изучения выявлен их высокий биологически активный потенциал. Показана возможность образовывать несколько видов тканей организма. Стволовые клетки, как и любые другие, оказывают свое воздействие на окружающие клетки и ткани путем выделения внеклеточных везикул. Внеклеточные везикулы стволовых клеток обладают биологической активностью родительских клеток. Принимая во внимание регенеративный потенциал мезенхимных стволовых клеток, в настоящее время их применяют в медицине, а также в ветеринарии для лечения различных травм животных-компаньонов. Были проведены исследования по изучению влияния мезенхимных стволовых клеток на сперматозоиды хряка и крысы при хранении в течение 12 ч. Согласно полученным результатам, мезенхимные стволовые клетки свиньи способствуют выживанию сперматозоидов хряка и сохранению их подвижности на 60–80% (в зависимости от растворителя) по сравнению с контролем в течение 12 ч соинкубирования. Однако такого значительного эффекта не наблюдали при соинкубировании сперматозоидов крыс с мезенхимными стволовыми клетками крысы. Но необходимо отметить, что до 3-го ч соинкубирования подвижность сперматозоидов в опыте была выше, чем в контроле. К 5-му ч наблюдения эта разница нивелировалась. Вероятно, сперматозоиды крысы и хряка имеют различные физиологические особенности, которые отразились на полученных результатах. Таким образом, показана возможность использования мезенхимных стволовых клеток для хранения и, возможно, криоконсервации спермы некоторых животных, но для этого требуется проведение дальнейших исследований.</p></abstract><trans-abstract xml:lang="en"><p>Mesenchymal stem cells (MSCs) have been known to mankind since the mid-20th century. The comprehensive study revealed their high biologically active potential. Capacity of forming several types of body tissues was demonstrated. The stem cells, like any other cells, exert their eﬀect on surrounding cells and tissues by secreting extracellular vesicles. The extracellular vesicles of the stem cells possess biological activity of parent cells. Taking into account the regenerative potential of the mesenchymal stem cells, they are currently used in medicine, and also in veterinary medicine for treatment of various injuries of the companion animals. Eﬀect of the mesenchymal stem cells on boar and rat sperm cells during 12-hour storage was studied. The study results demonstrated that during 12 hours of coincubation, the porcine MSCs contributed to the survival of the boar sperm cells and maintenance of their motility at 60–80% (depending on the solvent) as compared to the controls. Such a signiﬁcant eﬀect was not however observed during coincubation of the rat sperm cells with rat MSCs. But it should be noted that before the3rdhour of coincubation, the experimental sperm motility was higher than that of the control. By hour5 of the observation, this diﬀerence was leveled. The rat and boar sperm cells are likely to have diﬀerent physiological characteristics, which were reﬂected in the results obtained. Therefore, possibility of using the MSCs for the storage and cryopreservation of the semen of some animals was demonstrated, but this requires further research.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мезенхимные стволовые клетки</kwd><kwd>свинья</kwd><kwd>хряк</kwd><kwd>крыса</kwd><kwd>сперматозоиды</kwd></kwd-group><kwd-group xml:lang="en"><kwd>mesenchymal stem cells (MSCs)</kwd><kwd>pig</kwd><kwd>boar</kwd><kwd>rat</kwd><kwd>sperm cells</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено за счет гранта Российского научного фонда № 23-26-00172 в рамках Программы стратегического академического лидерства Казанского федерального университета («Приоритет-2030»).</funding-statement><funding-statement xml:lang="en">The study was carried out at the expense of a grant from the Russian Science Foundation No. 23-26-00172 within the framework of the Strategic Academic Leadership Program of Kazan Federal University ("Priority-2030").</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Епишина Т. 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