veterinaryВетеринария сегодняVeterinary Science Today2304-196X2658-6959"Veinard"10.29326/2304-196X-2021-2-37-166-172veterinary-567Research ArticleОБЩИЕ ВОПРОСЫGENERAL ISSUESИсследование воздействия термальной воды из источника региона Афьонкарахисар на содержание кальция и уровни некоторых гормонов в крови крыс с экспериментально воспроизведенным остеопорозомInvestigation of the effects of Afyonkarahisar Region hot springs water on blood calcium and some hormon levels in experimentally-created osteoporosis in ratshttps://orcid.org/0000-0003-3336-4479ElitokBülentElitokBülent

Elitok Bülent, доктор наук, доцент, кафедра терапии факультета ветеринарной медицины

03200, г. Афьонкарахисар

Bülent Elitok, Doctor of Science, Associate Professor, Department of Internal Medicine, Faculty of Veterinary Medicine

03200, Afyonkarahisar

elitok1969@hotmail.comSayginTolgahanSayginTolgahan

Tolgahan Saygin

Афьонкарахисар

Tolgahan Saygin

Afyonkarahisar

UlusoyYavuzUlusoyYavuz

Yavuz Ulusoy, доктор наук, заведующий лабораторией патологии

Анкара

Yavuz Ulusoy, Doctor of Science, Head of Pathology Laboratory

Ankara

yavuz.ulusoy@tarim.gov.trKilinçBahadirKilinçBahadir

Bahadir Kilinç, ветеринарный врач лаборатории патологии

Анкара

Bahadir Kilinç, Veterinarian, Pathology Laboratory

Ankara

bahadir.kilinc@tarim.gov.trУниверситет Афьон КоджатепеТурцияAfyon Kocatepe UniversityTurkeyЦентральный научно-исследовательский институт ветеринарного контроля, Министерство сельского и лесного хозяйстваТурцияVeterinary Control Central Research Institute, Ministry of Agriculture and ForestryTurkey20210107202102166172Copyright © Elitok B., Saygin T., Ulusoy Y., Kilinç B., 20212021Elitok B., Saygin T., Ulusoy Y., Kilinç B.Elitok B., Saygin T., Ulusoy Y., Kilinç B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://veterinary.arriah.ru/jour/article/view/567

На сегодняшний день одним из наиболее распространенных неинфекционных заболеваний, которое, по данным экспертов Всемирной организации здравоохранения, занимает ведущее место в структуре заболеваемости и смертности населения, является остеопороз. Целью настоящего исследования было определение влияния воды из термальных источников региона Афьонкарахисар на содержание кальция и уровни некоторых гормонов в крови крыс с воспроизведенным остеопорозом. В эксперименте использовали 25 самок крыс-альбиносов одного возраста. У всех животных под анестезией с использованием кетамина (200 мг/кг) и ксилазина (10 мг/кг) удалили яичники, после чего их разделили на две группы: контрольную (10 особей) и опытную (15 особей). Животных контрольной группы дважды в день через орогастральный зонд выпаивали водопроводной водой и в течение 15 минут в одно и то же время купали в ней, температура воды составляла (35 ± 2) °C. Животные опытной группы в том же режиме получали свежую воду из горячего источника Süreyya I. Клинические, гематологические и биохимические параметры крови измеряли до начала исследования, а также на 1, 7, 14 и 21-е сут после овариэктомии. Показано, что послеовариэктомии отмечались отклонения от нормы величин исследуемых показателей крови. В процессе лечения к 21-м сут эксперимента наблюдался процесс нормализации показателей, наиболее заметные изменения произошли у крыс опытной группы (p < 0,05). По итогам работы было установлено, что вода из термального источника Süreyya I способствовала значительному улучшению клинических, гематологических и биохимических показателей крови у крыс с остеопорозом, следовательно, ее можно использовать для профилактики и лечения данного заболевания в комплексе с другими видами лечения.

Today, one of the most common non-communicable diseases, which, according the World Health Organization experts, dominates the structure of human morbidity and mortality is osteoporosis. The aim of this study was to determine the effect of water from the hot springs of the Afyonkarahisar region on the calcium content and the levels of certain hormones in the blood of rats with experimentally induced osteoporosis. 25 female albino rats of the same age were used in the experiment. Ovaries were removed from all animals under anesthesia with ketamine (200 mg/kg) and xylazine (10 mg/kg), after which they were divided into two groups: control (10 animals) and experimental (15 animals). The animals of the control group were given tap water twice a day through an orogastric tube and they were bathed in it for 15 minutes at the same time, the water temperature was (35 ± 2) °C. The animals of the experimental group were given fresh water from the Süreyya I hot spring using the same method. Blood clinical, hematological and biochemical parameters were measured prior to the study, as well as on day 1, 7, 14, and 21 after the ovariectomy operation. The ovariectomy demonstrated inconsistence of the tested blood parameters with the standard ones. In the course of the treatment, by day 21 of the experiment, the parameters normalized, and the most noticeable changes were observed in the rats of the experimental group (p < 0.05). The results of the work performed showed that Süreyya I hot spring water contributed to a significant improvement in the clinical, hematological and biochemical blood parameters in rats with osteoporosis, therefore, it can be used for prevention and treatment of this disease in combination with other types of treatment.

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The authors declare that there are no conflicts of interest present.