veterinaryВетеринария сегодняVeterinary Science Today2304-196X2658-6959"Veinard"veterinary-175Research ArticleСтатьиВозможности метода капиллярного электрофореза при анализе готовых лекарственных средств антибактериального действияCapabilities of capillary electrophoresis for analysis of ready-to-use pharmaceutical products with an antibacterial effectБольшаковД. С.BolshakovD. S.bolshakov@arriah.ruАмелинВ. Г.AmelinV. G.noemail@neicon.ruНикешинаТ. Б.NikeshinaT. B.noemail@neicon.ruФГБУ «ВНИИЗЖ», г. ВладимирРоссияFGBI "ARRIAH", VladimirRussian Federation201502042018012936Copyright © Большаков Д.С., Амелин В.Г., Никешина Т.Б., 20182018Большаков Д.С., Амелин В.Г., Никешина Т.Б.Bolshakov D.S., Amelin V.G., Nikeshina T.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://veterinary.arriah.ru/jour/article/view/175

В работе оценена возможность контроля качества готовых лекарственных средств методами капиллярного электрофореза. Выбраны оптимальные условия разделения и определения различных классов антибактериальных веществ: пенициллинов, фторхинолонов, нитрофуранов, сульфаниламидов, метронидазола и хлорамфеникола. Диапазон определяемых содержаний действующих компонентов составил 1-2500 мг/г для твердых образцов и 0,001 -0,50% для жидких препаратов.

The capability to monitor quality of ready-to-use pharmaceuticals using capillary electrophoresis methods is evaluated in the paper. Optimal conditions for separation and determination of different classes of such antibacterial agents as penicillins, fluoroquinolones, nitrofurans, sulfanilamides, metronidazole and chloramphenicol are chosen. The range of content of active constituents is 1-2500 mg/g for solid samples and 0,001-0,50% for liquid preparations.

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The authors declare that there are no conflicts of interest present.